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KMID : 0363220090470010050
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Korean Journal of Dermatology
2009 Volume.47 No. 1 p.50 ~ p.54
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A Significance of High Levels of Total Serum IgE in Herpes Zoster
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Cha Sang-Hee
Cho Sang-Hyun
Lee Je-Hoon
Park Chul-Jong
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Abstract
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Backgroud: Herpes zoster is caused by the reactivation of varicella zoster virus. Many factors are involved in the
reactivation of viruses, but most of them are unknown, except for immunosuppression and old age. A relationship
between an increased level of total serum IgE and viral infection has been observed in a few previous studies.
Objective: The purpose of this study was to evaluate the quantitative changes, as well as the role of the total serum
IgE, in patients suffering with herpes zoster.
Methods: We retrospectively reviewed the medical records and laboratory data of 205 patients with herpes zoster.
We evaluated the clinical findings such as the affected dermatomes, the duration of illness and the persistence of
herpes zoster-associated pain. The relationships of the clinical findings and the level of total serum IgE, which was
measured by competitive chemiluminescence immunoassay, were also evaluated.
Results: The level of total serum IgE was elevated in 95 (46.3%) of 205 patients with herpes zoster and who did
not have any medical history that would influence the level of total serum IgE. The amount of elevation of the total
serum IgE was higher in the younger patient group than that in the older patient group. However, there were no
statistically significant relationships between the level of total serum IgE and the clinical features.
Conclusion: The level of total serum IgE in patients with herpes zoster was increased to more than the normal
level. This may contribute to an overt defect of the cellular immune system in patients with herpes zoster.
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KEYWORD
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Herpes zoster, Total serum IgE
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